"A different way to look at is it's almost impossible for evolution not to happen." Still, the findings also are controversial, because it's far from clear what effect the genetic changes had or if they arose when Lahn's "molecular clock" suggests — at roughly the same time period as some cultural achievements, including written language and the development of cities.
Other scientists urge great caution in interpreting the research.
That the genetic changes have anything to do with brain size or intelligence "is totally unproven and potentially dangerous territory to get into with such sketchy data," stressed Dr.
Francis Collins, director of the National Human Genome Research Institute.
Aside from not knowing what the gene variants actually do, no one knows how precise the model Lahn used to date them is, Collins added.
Lahn's own calculations acknowledge that the microcephalin variant could have arisen anywhere from 14,000 to 60,000 years ago, and that the uncertainty about the ASPM variant ranged from 500 to 14,000 years ago.